T311 Mouse Monoclonal

    Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxyphenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Clone T311 shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75.1 Staining of melanomas with clone T311 showed tyrosinase in melanotic as well as amelanotic variants.1 Ab-1 is a useful marker for melanocytes and melanomas. Occasionally a minor band at 55kDa is also detected in Western Blotting.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Isotype:IgG2a /κ
    Immunogen:Recombinant tyrosinase protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2074ML
    Classification IVD
    Catalogue Number Z2074ML
    Package Inserts
    IFU-Tyrosinase T311
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.