Zeta Corporation offers polymer-based detection to reduce non-specific staining and increase the signal-to-noise ratio of the immunohistochemistry application (IHC). Many of the human organs contain endogenous biotin that might interfere with the actual staining for IHC and require additional blocking steps. With the advent of polymer detection technology, the biotin was completely removed from the detection chemistry and thus reducing the “background” noise. However, the size of the polymer molecule also introduced the steric hindrance. Therefore, Zeta made sure that our detection polymers are small in size to avoid steric hindrance and help increase the sensitivity and specificity of the detection process.
Zeta Corporation has developed and released two different detection chemistries to fit every laboratory needs. They are both universal detection chemistries, meaning they could detect both mouse and rabbit primary antibodies on human tissue specimens. To offer more sensitive detection for some of the low-expressing nuclear primary antibodies, Zeta introduced the Zeta MAX detection kits with an amplification step specifically targeting mouse primary antibodies.