Preferred Clone
Formalin-fixed, paraffin-embedded human liver with metastatic melanoma stained with anti-PRAME antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining in tumor cells
Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. This gene encodes an antigen that is preferentially expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. The encoded protein acts as a repressor of retinoic acid receptor, and likely confers a growth advantage to cancer cells via this function. Alternative splicing results in multiple transcript variants.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Testis or melanoma
Visualization:Nucleus, cytoplasm, cell surface, chromosome, Golgi apparatus.
Isotype:IgG
Immunogen:Recombinant fragment (around aa100-509) of human PRAME protein
Ordering Information
Package Inserts
IFU-PRAME ZR383 - IVD 0
SDS