ZM10 Monospecific Mouse Monoclonal

    Sry-related HMG-BOX gene 10, (SOX-10), a nuclear transcription factor that participates in neural crest development and in the specification and differentiation of cells of melanocytic lineage, has been recently shown to be a sensitive marker of melanoma. SOX-10 nuclear expression was found in virtually all cases of melanomas (97%) and about half of cases of malignant peripheral nerve sheath tumors (49%). In sentinel node, SOX-10 is positive in metastatic melanomas and nodal capsular nevus but not in dendritic cells, which usually express S100 protein. SOX-10 is moderately to strongly positive in desmoplastic or spindle cell melanomas, which is usually negative for HMB-45, Melan-A or even S-100. SOX-10 is diffusely expressed in schwannomas, neurofibromas, sustentacular cells of pheochromocytomas and paragangliomas. SOX-10 reaction is not identified in any other mesenchymal and epithelial tumors except for myoepitheliomas and diffuse astrocytomas.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Isotype:IgG2b /κ
    Immunogen:Recombinant human SOX10 protein fragment (around aa 115-269)
    Ordering Information
    Classification IVD
    Catalogue Number Z2293ML
    Classification IVD
    Catalogue Number Z2293ML
    Package Inserts
    IFU-SOX-10 ZM10
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.