ZM385 Mouse Monoclonal

    Transcriptional regulators play a critical role in development by mediating tissue- and cell-specific transcription. POU domain factors are transcriptional regulators characterized by a bipartite DNA binding domain consisting of two highly conserved regions, tethered by a variable linker of 14-26 amino acids. Pit-1, also known as growth hormone factor-1 (GHF-1), a member of the POU homeodomain family, is essential for the normal development of the anterior pituitary gland, where it is required to form of somatotropes, lactotropes, and thyrotropes. In somatotropes and lactotropes, Pit-1 activates the production of growth hormone and prolactin, respectively. In addition, Pit-1 acts as a repressor of gene expression, which allows for the differentiation of specific cell types. Pit-1 is expressed as two alternatively spliced products, designated Pit-1a and Pit-1b, which differ in their trans-activation ability. Mutations in the Pit-1 gene are believed to result in combined pituitary hormone deficiency (CPHD) for growth hormone, Prolactin, and thyroid-stimulating hormone. The gene which encodes Pit-1 maps to human chromosome 3p11.2.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Isotype:IgG2b /κ
    Immunogen:Recombinant human full-length POU1F1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2676ML
    Classification IVD
    Catalogue Number Z2676ML
    Package Inserts
    IFU-PIT-1 ZM385
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.