Cytokeratin 8/18

    General & Epithelial Markers
    ZM125 Mouse Monoclonal

    Cytokeratin 8 (CK8) belongs to the type II (or B or basic) subfamily of high molecular weight cytokeratins and exists in combination with cytokeratin 18 (CK18). This MAb recognizes all simple epithelia including glandular epithelium, for example thyroid, female breast, gastrointestinal tract, respiratory tract, and urogenital tract including transitional epithelium. All adenocarcinomas and most squamous carcinomas are positive but keratinizing squamous carcinomas are usually negative. This antibody is useful in demonstrating the presence of Paget cells; there is very little keratin 18 in the normal epidermis so only Paget cells are stained.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Skin, breast carcinoma
    Isotype:IgG1 /κ
    Immunogen:Cytoskeleton preparation from HeLa cells
    Ordering Information
    Classification IVD
    Catalogue Number Z2435ML
    Classification IVD
    Catalogue Number Z2435ML
    Package Inserts
    IFU-Cytokeratin 8/18 ZM125
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.