Podoplanin

Zeta’s recombinant rabbit antibody to Podoplanin (PDPN) recognizes a muco-protein of 38-43kDa located in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin plays a role in maintaining the unique shape of podocytes. Podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, podoplanin can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.