Preferred Clone
Human mesothelioma stained with anti-calretinin antibody using peroxidase-conjugate and DAB chromogen. Note nuclear/cytoplasmic staining of mesothelioma cells.
It recognizes a protein of about 29kDa, which is identified as Calretinin (also known as Calbindin 2). Calretinin is a vitamin D-dependent calcium-binding protein involved in calcium signaling. It is present in subsets of neurons throughout the brain and spinal cord, including sensory ganglia. Antibody to calretinin is useful in differentiating mesothelioma from adenocarcinomas of the lung. It also aids in differentiating adrenal cortical neoplasms from pheochromocytomas.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Mesothelioma
Visualization:Cytoplasmic and nuclear
Isotype:IgG1 /κ
Immunogen:Recombinant human Calretinin (Calbindin 2) protein fragment (around aa23-242)
Ordering Information
Package Inserts
SDS