Vascular Markers
    JC70A Mouse Monoclonal

    CD31 is a glycoprotein expressed on endothelial cells and in platelets. It is known to be involved in cell signaling and cell adhesion. JC/70A reacts with endothelial cells in normal tissues and in benign and malignant proliferations.1 In cryostat sections and blood smears the antibody also stains megakaryocytes, platelets and occasionally plasma cells.1 It reacts weakly with mantle zone B cells, peripheral T cells, and neutrophils. Antibody to CD31 is of value in the study of benign and malignant vascular tumors. Staining for CD31 has also been used to measure angiogenesis, which reportedly predicts tumor recurrence.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Visualization:Cell membrane
    Isotype:IgG1 /κ
    Immunogen:Preparation of a spleen from a patient with hairy cell leukemia
    Ordering Information
    Classification IVD
    Catalogue Number Z2136ML
    Classification IVD
    Catalogue Number Z2136ML
    Package Inserts
    IFU-CD31 JC70A
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.