Human angiosarcoma stained with anti-CD31 antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor cells.

CD31

Vascular Markers

JC70A Mouse Monoclonal

CD31 is a glycoprotein expressed on endothelial cells and in platelets. It is known to be involved in cell signaling and cell adhesion. JC/70A reacts with endothelial cells in normal tissues and in benign and malignant proliferations.1 In cryostat sections and blood smears the antibody also stains megakaryocytes, platelets and occasionally plasma cells.1 It reacts weakly with mantle zone B cells, peripheral T cells, and neutrophils. Antibody to CD31 is of value in the study of benign and malignant vascular tumors. Staining for CD31 has also been used to measure angiogenesis, which reportedly predicts tumor recurrence.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Placenta

Visualization:Cell membrane

Isotype:IgG1 /κ

Immunogen:Preparation of a spleen from a patient with hairy cell leukemia

Ordering Information

USA International

Package Inserts

IFU-CD31 JC70A

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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