Gynecological Pathology
    JC2 Mouse Monoclonal

    p16INK4a is a tumor suppressor protein. It is a specific inhibitor of cdk4/cdk6, and a tumor suppressor involved in the pathogenesis of a variety of malignancies. Recent analyses of the p16INK4a gene revealed homozygous deletions, nonsense, missense, or frameshift mutations in several human cancers. Although the frequency of p16INK4a abnormalities is higher in tumor-derived cell lines than in unselected primary tumors, significant subsets of clinical cases with aberrant p16INK4a gene have been reported among melanomas, gliomas, esophageal, pancreatic, lung, and urinary bladder carcinomas, and some types of leukemia. Expression of p16INK4a (p16 positive) is highly correlated with human papilloma virus (HPV) infection in head and neck squamous cell carcinomas (HNSCC). p16INK4a status is an important prognostic indicator in HNSCC and the p16INK4a positive/HPV16 negative group is likely a distinct subgroup lacking any HPV genotype.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Cervical squamous cell carcinoma
    Visualization:Cytoplasmic and nuclear
    Isotype:IgG2a /κ
    Immunogen:Purified recombinant prokaryotic full length human p16INK4a protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2567ML
    Classification IVD
    Catalogue Number Z2567ML
    Package Inserts
    IFU-p16INK4a JC2
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.