Human lung adenocarcinoma stained with anti-Napsin-A antibody using peroxidase-conjugate and DAB chromogen. Note cytopasmic staining carcinoma cells.

Napsin-A

Lung/Mediastinum Pathology

ZM11 Monospecific Mouse Monoclonal

Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Lung adenocarcinoma

Visualization:Cytoplasmic

Isotype:IgG1 /κ

Immunogen:Recombinant fragment of human napsin protein

Ordering Information

USA International

Package Inserts

IFU-Napsin-A ZM11

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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