TTF-1/NKX2.1

    Lung/Mediastinum Pathology
    ZR176 Rabbit Monoclonal

    Zeta’s rabbit recombinant monoclonal antibody recognizes TTF-1/NKX2.1, a protein of 40kDa, identified as Thyroid transcription factor-1. TTF-1 is a member of the NKx2 family of homeodomain transcription factors. TTF-1/NKX2.1 is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma.  Zeta antibody to TTF-1/NKX2.1 can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal thyroid or lung
    Visualization:Nuclear
    Isotype:IgG1 /κ
    Immunogen:Recombinant TTF-1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2370RL
    Classification IVD
    Catalogue Number Z2370RL
    Package Inserts
    IFU-TTF-1/NKX2.1 ZR176
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS