MiTF (Microphthalmia)

    Dermatopathology
    C5/D5 Mouse Monoclonal

    Zeta MiTF Antibody.  Zeta’s mouse monoclonal antibody recognizes MiTF (Microphthalmia), a basic helix-loop-helix-leucin zipper (b-HLH-ZIP) transcription factor implicated in pigmentation, mast cells and bone development. The mutation of the MiTF gene causes Waardenburg syndrome type II in humans. In mice, a profound loss of pigmented cells in the skin eye and inner ear results, as well as osteopetrosis and defects in natural killer and mast cells. There are two known isoforms of MiTF differing by 66 amino acids at the NH2 terminus. Shorter forms are expressed in melanocytes and run as two bands at 52kDa and 56kDa, while the longer MiTF form runs as a cluster of bands at 60-70kDa in osteoclasts and in B16 melanoma cells (but not other melanoma cell lines), as well as mast cells and heart. Clone D5 cocktail is especially designed for sensitive detection of Mi protein. C5 reacts with both melanocytic and non-melanocytic isoforms of MiTF.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Melanoma
    Visualization:Nuclear
    Isotype:IgG1 /κ / IgG1 /κ
    Immunogen:N-terminal fragment of human Mi protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2161ML
    Classification IVD
    Catalogue Number Z2161ML
    Package Inserts
    IFU-MiTF (Microphthalmia) C5/D5
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS