Related Products


    Soft Tissue Pathology
    G146-22 Mouse Monoclonal

    The FLI-1 gene and FLI-1 protein are best known for their critical role in the pathogenesis of ES/PNET. More than 85% of ES/PNET are characterized by the translocation t(11;22) (q24;q12) that results in the fusion of the EWS gene on chromosome 22 to the FLI-1 gene on chromosome 11. FLI-1 is a member of the ETS (erythroblastosis virus-associated transforming sequences) family of DNA-binding transcription factors and is involved in cellular proliferation and tumorigenesis. FLI-1 is normally expressed in endothelial cells and in hematopoietic cells, including T lymphocytes. The immunohistochemical detection of FLI-1 protein has been shown to be valuable in the discrimination of ES/PNET from most of its potential mimics, with the notable exception of lymphoblastic lymphoma. The FLI-1 gene has also been shown to play an important role in the embryologic development of blood vessels. FLI-1 expression in the nonvascular sarcomas, melanomas, or carcinomas studied was not observed.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Ewing's sarcoma/PNET, lymphoblastic lymphoma, lymphocytes, endothelial cells, angiosarcoma, Kaposi's sarcoma
    Isotype:IgG1 /κ
    Immunogen:FLI-1 ETS domain fusion protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2146ML
    Classification IVD
    Catalogue Number Z2146ML
    Package Inserts
    IFU-FLI-1 G146-22
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.