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    NKX2.2

    Soft Tissue Pathology
    ZM14 Monospecific Mouse Monoclonal

    Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Ewing's sarcoma
    Visualization:Nuclear
    Isotype:IgG1 /κ
    Immunogen:Human recombinant NKX2.2 protein fragment (aa 1-119)
    Ordering Information
    Classification IVD
    Catalogue Number Z2348ML
    Classification IVD
    Catalogue Number Z2348ML
    Package Inserts
    IFU-NKX2.2 ZM14
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS