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    Soft Tissue Pathology
    ZR217 Rabbit Monoclonal

    Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified based on homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing’s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22) (q24;q12), which results in the fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues, only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in most vascular tumors, including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi’s Sarcomas. The high sensitivity and specificity of Fli-1 equal or exceed that of the established vascular markers like CD31, CD34, and Factor VIII.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Ewing's sarcoma/PNET, lymphoblastic lymphoma, lymphocytes, endothelial cells, angiosarcoma, Kaposi's sarcoma
    Immunogen:Recombinant full-length human FLI1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2498RL
    Classification IVD
    Catalogue Number Z2498RL
    Package Inserts
    IFU-FLI-1 ZR217
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.