Zeta Desmoglein-3 Antibody. Zeta’s recombinant rabbit antibody recognizes Desmoglein-3 (DSG3), a calcium-binding transmembrane glycoprotein component desmosomes in vertebrate epithelial cells. The Desmoglein-3 antibody recognizes a protein of 130kDa, identified and does not cross-react with other members of the Desmoglein family. Desmoglein-3 (DSG3) is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that Desmoglein-3 (DSG3) antibodies have a very high sensitivity (80%) and specificity (100%) in recognizing squamous cell carcinoma (SqCC). Therefore, Desmoglein-3 (DSG3) is considered an important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that Desmoglein-3 (DSG3) expression in lung SqCC may indicate a poor prognosis.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.