SOX-2

    Dermatopathology
    ZM57 Monospecific Mouse Monoclonal

    Zeta SOX-2 Antibody.  Zeta’s recombinant mouse antibody recognizes SOX-2 (SRY (sex determining region Y)-box 2), a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX-2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. SOX-2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX-2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression.  SOX-2 is expressed in teratoma and CNS astrocytic tumors.  SOX-2 is a marker of embryonic stem cell pluripotency that is associated with aggressive tumor behavior.  SOX-2 is expressed in CNS tumors: glial tumors, supratentorial PNET, but not medulloblastoma or pineoblastoma.  SOX-2 is also expressed in embryonal carcinoma of mediastinum and testis.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal brain tissue and astrocytoma
    Visualization:Nuclear
    Isotype:IgG2b /κ
    Immunogen:Recombinant human SOX2 protein fragment (around aa176-305)
    Ordering Information
    Classification IVD
    Catalogue Number Z2367ML
    Classification IVD
    Catalogue Number Z2367ML
    Package Inserts
    IFU-SOX-2 ZM57
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS