Cytokeratin 5

    General & Epithelial Markers
    ZM186 Monospecific Mouse Monoclonal

    T+P112his MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations KRT5 have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB). Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Isotype:IgG1 /κ
    Immunogen:Recombinant human Cytokeratin 5 (KRT5) protein fragment (around aa 318-491)
    Ordering Information
    Classification IVD
    Catalogue Number Z2505ML
    Classification IVD
    Catalogue Number Z2505ML
    Package Inserts
    IFU-Cytokeratin 5 ZM186
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.