preferred clone

Formalin-fixed, paraffin-embedded human prostate stained with anti-keratin 5 antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of basal cells in normal glands and negative stain in prostate carcinoma

Cytokeratin 5

General & Epithelial Markers

ZR280 Rabbit Monoclonal

This MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations KRT5 have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB). Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins are helpful markers of tissue differentiation, directly applicable to the characterization of malignant tumors.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Prostate

Visualization:Cytoplasmic

Isotype:IgG1

Immunogen:Recombinant human Cytokeratin 5 (KRT5) protein fragment (around aa 318-491)

Ordering Information

USA International

Package Inserts

IFU-Cytokeratin 5 ZR280

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

Accept Reject

SDS