Cytokeratin 5

    General & Epithelial Markers
    ZR280 Rabbit Monoclonal

    This MAb recognizes a protein of 58kDa, which is identified as Cytokeratin 5 (KRT5). This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations KRT5 have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB). Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins are helpful markers of tissue differentiation, directly applicable to the characterization of malignant tumors.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Immunogen:Recombinant human Cytokeratin 5 (KRT5) protein fragment (around aa 318-491)
    Ordering Information
    Classification IVD
    Catalogue Number Z2595RL
    Classification IVD
    Catalogue Number Z2595RL
    Package Inserts
    IFU-Cytokeratin 5 ZR280
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.