Soft Tissue Pathology
    ZR413 Rabbit Monoclonal

    Recognizes a protein of 150kDa, which is identified as the high molecular weight variant of Caldesmon. Two closely related variants of human caldesmon have been identified, which are different in their electrophoretic mobility and cellular distribution. The h-caldesmon variant (120’150kDa) is predominantly expressed in smooth muscle, whereas l-caldesmon (70’80kDa) is found in non-muscle tissue and cells. Neither of the two variants has been detected in skeletal muscle. This MAb recognizes only the 150kDa variant (h-caldesmon) in Western blots of human aortic media extracts and is unreactive with fibroblast extracts from cultivated human foreskin. Caldesmon is a developmentally regulated protein involved in smooth muscle and non-muscle contraction.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Uterus, colon carcinoma
    Immunogen:Recombinant full-length human CALD1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2769RL
    Classification IVD
    Catalogue Number Z2769RL
    Package Inserts
    IFU-Caldesmon ZR413
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.