Human skin stained with anti-SOX-2 antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of keratinocytes..

SOX-2

Dermatopathology

ZM57 Monospecific Mouse Monoclonal

SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. It is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct3/4 expression.SOX-2 is expressed in teratoma and CNS astrocytic tumors.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Normal brain tissue and astrocytoma

Visualization:Nuclear

Isotype:IgG2b /κ

Immunogen:Recombinant human SOX2 protein fragment (around aa176-305)

Ordering Information

USA International

Package Inserts

IFU-SOX-2 ZM57

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS