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    Soft Tissue Pathology
    ZR444 Rabbit Monoclonal

    Recognizes a 105kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. It shows no cross reaction with p107 or p130. It reacts with the hyper-phosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma. Some tumors, with Rb gene mutations, are negative for Rb, such as spindle cell lipoma and breast myofibroblastomas,

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Colon cancer
    Immunogen:Recombinant human Rb1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2800RL
    Classification IVD
    Catalogue Number Z2800RL
    Package Inserts
    IFU-Rb ZR444
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.