Related Products


    Soft Tissue Pathology
    SMP14 Mouse Monoclonal

    p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of co-transfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wide type p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. These findings argue that MDM2 overexpression (gene amplification) represents at least one mechanism by which p53 function can be abrogated during tumorigenesis. MDM2 is useful in differentiating well-differentiated/dedifferentiated liposarcoma from other types of sarcomas.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Isotype:IgG1 /κ
    Immunogen:Amino acids 154-167 of MDM2 of human origin
    Ordering Information
    Classification IVD
    Catalogue Number Z2189ML
    Classification IVD
    Catalogue Number Z2189ML
    Package Inserts
    IFU-MDM2 SMP14
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.