Zeta PHOX2B Antibody. Zeta’s rabbit recombinant antibody recognizes PHOX2B (Paired homeobox protein 2B), a transcription factor located on chromosome 4p13, which is essential for forming autonomic ganglia in the autonomic nervous system. PHOX2B is expressed in neuroblastoma (NB), brain, and adrenal glands. PHOX2B deficiency can lead to susceptibility to congenital central hypoventilation syndrome (CCHS) and neuroblastoma type 2 (NBLST2). PHOX2B is a gene essential in the development of the autonomic nervous system.
PHOX2B is a useful marker of Neuroblastoma (NB). PHOX2B is specific for NB in its differential diagnosis with other small round cell tumors, and PHOX2B nuclear staining may be helpful for accurate bone marrow tumor quantification. Although most cases of NB show distinct and recognizable histology, a subset with small round blue cell morphology require a panel of immunohistochemical stains to permit distinction from other tumors of childhood, such as rhabdomyosarcoma, Wilms tumor, Ewing sarcoma, and lymphoma.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.