PHOX2B

    Neuropathology/Endocrine
    ZR292 Rabbit Monoclonal

    Zeta PHOX2B Antibody.  Zeta’s rabbit recombinant antibody recognizes PHOX2B (Paired homeobox protein 2B), a transcription factor located on chromosome 4p13, which is essential for forming autonomic ganglia in the autonomic nervous system. PHOX2B is expressed in neuroblastoma (NB), brain, and adrenal glands. PHOX2B deficiency can lead to susceptibility to congenital central hypoventilation syndrome (CCHS) and neuroblastoma type 2 (NBLST2).  PHOX2B is a gene essential in the development of the autonomic nervous system.

    PHOX2B is a useful marker of Neuroblastoma (NB). PHOX2B is specific for NB in its differential diagnosis with other small round cell tumors, and PHOX2B nuclear staining may be helpful for accurate bone marrow tumor quantification. Although most cases of NB show distinct and recognizable histology, a subset with small round blue cell morphology require a panel of immunohistochemical stains to permit distinction from other tumors of childhood, such as rhabdomyosarcoma, Wilms tumor, Ewing sarcoma, and lymphoma.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Neuroblastoma
    Visualization:Nuclear
    Isotype:IgG
    Immunogen:Recombinant fragment of human PHOX2B protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2730RL
    Classification IVD
    Catalogue Number Z2730RL
    Package Inserts
    IFU-PHOX2B ZR292
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS