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    Myogenin

    Soft Tissue Pathology
    ZM149 Mouse Monoclonal

    Zeta Myogenin Antibody.  Zeta’s recombinant mouse antibody recognizes Myogenin, a member of the MyoD family of myogenic basic helix-loop-helix (bHLH) transcription factors expressed early in skeletal muscle differentiation that also includes MyoD, Myf-5, and MRF4.  Myogenin is a sensitive and specific for rhabdomyosarcoma.

    MyoD family members are expressed exclusively in skeletal muscle and play a key role in activating myogenesis by binding to enhancer sequences of muscle-specific genes. The regulatory domain of MyoD is approximately 70 amino acids in length and includes both a basic DNA binding motif and a bHLH dimerization motif. MyoD family members share about 80% amino acid homology in their bHLH motifs.

    The Myogenin antibody labels the nuclei of myoblasts in developing muscle tissue and is expressed in tumor cell nuclei of rhabdomyosarcoma and some leiomyosarcomas.  Myogenin provides focal nuclear staining in desmoid tumors, infantile myofibromatosis, synovial sarcoma, infantile fibrosarcoma, entrapped atrophic or regenerative skeletal muscle.  The Myogenin antibody has positive nuclear staining may occur in Wilms’ tumor.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Rhabdomyosarcoma or Wilm's tumor
    Visualization:Nuclear
    Isotype:IgG1 /κ
    Immunogen:Human myogenin recombinant protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2462ML
    Classification IVD
    Catalogue Number Z2462ML
    Package Inserts
    IFU-Myogenin ZM149 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS