Urinary Pathology
    ZR1 Rabbit Monoclonal

    PAX-8 is expressed in the thyroid, non-ciliated mucosal cells of the fallopian tubes and simple ovarian inclusion cysts, but not normal ovarian surface epithelial cells. PAX-8 is expressed in ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas. Over 98% of clear cell RCCs, 90% of papillary RCCs, and 95% of oncocytomas were positive for PAX-8. Similarly, the absence of expression of PAX-8 in breast and other non-GYN carcinomas other than those primary to the thyroid indicates that PAX-8 is an important new marker of ovarian cancer and a useful marker for the differential diagnoses in lung and neck tumors, or tumors at distant sites where primary lung carcinoma or thyroid carcinoma are possibilities. PAX-8, combined with organ system-specific markers such as uroplakin, mammaglobin, and TTF-1 can be a very useful panel to determine the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast. Unlike the polyclonal anti-PAX-8 antibody, the ZR1 rabbit monoclonal antibody does not react with pancreatic neuroendocrine tumors, thymic tumors, and lymphocytes.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Ovarian serous carcinoma
    Isotype:Rabbit IgG
    Immunogen:Synthetic peptide corresponding to the C-terminus of Human PAX8 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2202RL
    Classification IVD
    Catalogue Number Z2202RL
    Package Inserts
    IFU-PAX-8 ZR1 - IVD0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.