Human rhabdomyosarcoma stained with anti-Myogenin antibody using peroxidase-conjugate and DAB chromogen. Note nuclear staining of tumor cells.

Myogenin

Soft Tissue Pathology

F5D Mouse Monoclonal

Myogenin is a member of a family of myogenic regulatory genes, which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors, which are essential for muscle development. Transfection of myogenin into multipotential mesodermal cells have been shown to convert the mesodermal cells to myoblasts. Expression of myogenin is restricted to cells of skeletal muscle origin. It is therefore a useful marker for tumors of the muscle lineage, being strongly expressed in alveolar rhabdomyosarcomas.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Rhabdomyosarcoma

Visualization:Nuclear

Isotype:IgG1 /κ

Immunogen:Recombinant protein containing rat myogenin aa 30-224

Ordering Information

USA International

Package Inserts

IFU-Myogenin F5D

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS