Zeta MUC-2 Antibody. Zeta’s recombinant rabbit antibody recognizes MUC-2 (Mucin 2), the major intestinal secreted epithelial mucin, a large macromolecule that exhibit extreme polydispersity. MUC-2 is an important secretory protein found in the human gut. Recent studies indicated that MUC2 mucin plays a role in the protection of gut barrier, the regulation of microbiome homeostasis and the prevention of diseases.
Secreted MUC-2 mucin constitutes the major structural component of the mucus in the colon. The inner mucus layer is impervious to bacteria and provides a protective barrier for the colon epithelium. The downregulation of MUC-2 expression eliminates this protective mucus barrier, creating a microenvironment in which bacteria can contact the epithelial surface and activate an inflammatory response.
Chronic inflammation leads to cellular damage and molecular changes that transform the inflamed epithelium to low-grade dysplasia (LGD), high-grade dysplasia (HGD), and finally CRC. Functionally, MUC2 inhibits the intestinal inflammatory response, thus suppressing the development of intestinal tumors while decreased MUC2 expression contributes to CRC by promoting interleukin-6-induced epithelial to mesenchymal transition (EMT), thereby influencing the invasiveness of cancer cells.
In terms of expression, MUC-2 is a relatively specific marker for predicting the colorectal origin for Paget disease. MUC-2 is expressed in the intestinal and airway epithelium, mucinous carcinoma of colon, breast, pancreas, ovary and stomach, but MUC-2 is not expressed in the stomach, breast ductal and lobular carcinomas.
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