Zeta Inhibin-α Antibody. Zeta’s recombinant mouse antibody recognizes Inhibin-α, a gonadal protein that preferentially suppresses the secretion of pituitary follicle-stimulating hormone (FSH). The Inhibin-α antibody binds a 47kDa protein, which is identified as alpha sub-unit of Inhibin. Inhibin comprises two subunits, Inhibin A and Inhibin B. Each subunit consists of the same α subunit, covalently linked to 1 of 2 distinct subunits, β-α or β-β. Originally isolated from ovarian follicular fluid and characterized as a disulphide-linked dimeric glycoprotein, Inhibin-α belongs to the transforming growth factor β (TFGβ) superfamily. Antibodies against Inhibin-α are useful in making a differentiation between adrenal cortical tumors and renal cell carcinoma. Inhibin-α can also be used to identify the sex cord stromal tumors of the ovary as well as trophoblastic tumors also demonstrate cytoplasmic positivity. The Inhibin-α antibody is also used to make the differential diagnosis of intra-uterine versus ectopic pregnancy in endometrial curetting.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.