General & Epithelial Markers
    ZR133 Rabbit Monoclonal

    In Western blotting, it recognizes proteins in the MW range of 265-400kDa, identified as different glycoforms of EMA. EMA may provide a protective layer on epithelial cells against bacterial and enzyme attacks. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinomas. Anti-EMA antibody is a valuable marker for staining many carcinomas. It stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands, and colorectal carcinoma. Hepatocellular carcinoma, adrenal carcinoma, and embryonal carcinomas are consistently EMA negative, so keratin positivity with negative EMA favors one of these tumors. EMA is frequently positive in meningioma, which can be helpful when distinguishing it from other intracranial neoplasms such as schwannomas. Antibody to EMA is helpful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Breast or colon carcinoma
    Visualization:Cytoplasmic and membranous
    Immunogen:Recombinant full-length human MUC1 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2684RL
    Classification IVD
    Catalogue Number Z2684RL
    Package Inserts
    IFU-EMA ZR133
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.