Zeta Cytokeratin 5 Antibody. Zeta recombinant rabbit antibody recognizes Cytokeratin 5 (CK5 or KRT5), which is preferred to K903 in antibody cocktails for the detection of prostate carcinoma. The Cytokerating 5 antibody recognizes a protein of 58kDa, a type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in Cytokeratin 5 have been shown to result in the autosomal dominant disorder epidermolysis bullosa (EB). Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins are helpful markers of tissue differentiation, directly applicable to the characterization of malignant tumors.
Cytokeratin 5 (CK5) is preferred to K903 in antibody cocktails for the detection of prostate carcinoma and together with p63+, identify squamous origin in poorly differentiated metastatic carcinomas. Cytokeratin 5 can identify breast basal (myoepithelial cells) and prostate basal cells and distinguish breast usual ductal hyperplasia (UDH) and papillary lesions (mosaic-like pattern) from DCIS (usually negative, rarely diffusely positive). Cytokeratin 5 can distinguish epithelioid mesothelioma (CK5/6+ in 83%) from lung adenocarcinoma (CK5/6- in 85%), including in pleural effusions (CK5/6+ in 90% mesothelioma, 0% adenocarcinoma) and cutaneous spindle squamous cell carcinoma (CK5/6+ in 100%) from superficial epithelioid sarcoma. Cytokeratin 5 can be used as part of panel to distinguish cutaneous metastasis of breast cancer from sweat gland carcinoma
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