Cyclin D1

    Hematopathology
    ZR197 Rabbit Monoclonal

    Zeta Cyclin D1 Antibody.  Zeta’s recombinant rabbit antibody recognizes Cyclin D1 (known as PRAD-1 or bcl-1), one of the key cell cycle regulators, and functions in association with CDK4 and CDK6 by phosphorylating the Rb protein. Cyclin D1 is a putative proto-oncogene over expressed in a wide variety of human neoplasms including mantle cell lymphomas (MCL).

    Zeta’s recombinant mouse antibody recognizes Cyclin D1, one of the key cell cycle regulators, is a putative proto-oncogene overexpressed in a wide variety of human neoplasms. Cyclin D1 is a protein of 36kDa. The Cyclin D1 antibody neutralizes the activity of Cyclin D1 in vivo. About 60% of mantle cell lymphomas (MCL) contain a t(11; 14)(q13; q32) translocation resulting in over-expression of Cyclin D1. The Cyclin D1 antibody is useful in identifying mantle cell lymphomas (Cyclin D1 positive) from CLL/SLL and follicular lymphomas (Cyclin D1 negative). Occasionally, hairy cell leukemia and plasma cell myeloma weakly express Cyclin D1.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Mantle cell lymphoma
    Visualization:Nuclear
    Isotype:IgG
    Immunogen:A synthetic peptide from C-terminus of human cyclin D1
    Ordering Information
    Classification IVD
    Catalogue Number Z2515RL
    Classification IVD
    Catalogue Number Z2515RL
    Package Inserts
    IFU-Cyclin D1 ZR197 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS