Soft Tissue Pathology
    ZR394 Rabbit Monoclonal

    Cyclin-dependent kinase-4 (CDK4) is a protein-serine kinase involved in the cell cycle. It is essential for the G1- to S-phase transition during the cell cycle and its expression is primarily controlled at the transcriptional level. CCND1- CDK4 axis is not only critical in glial tumor cells but also in stromal-derived cells in the surrounding tumor microenvironment that are vital to sustaining tumor outgrowth. CDK4 is highly expressed in highly differentiated and dedifferentiated liposarcomas but rarely expressed in other benign liposarcomas and other sarcomas. CDK4 and MDM2 combined to differentiate between highly differentiated liposarcoma (+), dedifferentiated liposarcoma (+), and myxoid liposarcoma, pleomorphic liposarcoma, spindle lipoma, pleomorphic lipoma, and other high-grade sarcomas.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Urothelial carcinoma, well-differentiated liposarcoma
    Visualization:Nucleus and cytoplasm
    Immunogen:Recombinant fragment corresponding to N-terminal of human CDK4 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2750RL
    Classification IVD
    Catalogue Number Z2750RL
    Package Inserts
    IFU-CDK4 ZR394
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.