CD57

    Neuropathology/Endocrine
    NK-1 Mouse Monoclonal

    Zeta CD57 Antibody.  Zeta’s recombinant mouse antibody recognizes CD57, which is expressed on a subpopulation of 15-20% of peripheral blood mononuclear cells, about 60% of NK active cells and on a subset of T cells. Clone NK1 marks a subset of lymphocytes known as natural killer (NK) cells. Clone NK1 also reacts with a variety of cell types in non-lymphoid tissues. It stains neuroendocrine cells and their tumors.

    CD57 (also called Leu7, beta-1,3-glucuronyltransferase 1 and glucuronosyltransferase P) is a glycoprotein with cell adhesion functions that may define a phenotype associated with replicative senescence in HIV specific CD8+ T cells. CD57 is a marker of NK cells and neuroendocrine tumors, helps distinguish high grade prostatic adenocarcinoma (CD57+) from high grade urothelial carcinoma (CD57-).

    In normal cells, the CD57 antibody stains NK subset, T cell subset, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules.  In disease, CD57 is express in leukemias and lymphomas for autoimmune lymphoproliferative syndrome, hepatosplenic T cell lymphoma (some), nodular lymphocyte predominant Hodgkin lymphoma, pre T-ALL (occasional) and T-cell large granular lymphocytic leukemia.   It is also helpful for nerve sheath origin lesions including benign epithelioid nerve sheath tumor, chordoma, dendritic cell neurofibroma with pseudorosettes, melanotic neuroectodermal tumor of infancy, MPNST (expression decreases with tumor grade, and nerve sheath myxoma.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lymph node or tonsil
    Visualization:Cell membrane
    Isotype:IgM
    Immunogen:Human peripheral blood mononuclear cells
    Ordering Information
    Classification IVD
    Catalogue Number Z2111ML
    Classification IVD
    Catalogue Number Z2111ML
    Package Inserts
    IFU-CD57 NK-1 -IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS