Zeta CD3 Antibody. Zeta’s mouse recombinant antibody reacts with the intracytoplasmic portion of the CD3 antigen expressed by T cells. The Zeta CD3 antibody stains human T cells in both the cortex and medulla of the thymus and in peripheral lymphoid tissues. This CD3 antibody is suitable for staining normal and neoplastic T cells in formalin-fixed, paraffin-embedded tissues.
Specifically, Zeta’s antibody to CD3 recognizes the epsilon chain of CD3, which consists of five different polypeptide chains (designated as gamma, delta, epsilon, zeta, and eta) with MW ranging from 16-28kDa. The CD3 complex is closely associated with the T cell antigen receptor (TCR) at the lymphocyte cell surface. Reportedly, the CD3 complex is involved in signal transduction to the T cell interior following antigen recognition. The CD3 antigen is first detectable in early thymocytes and probably represents one of the earliest signs of commitment to the T cell lineage. In cortical thymocytes, CD3 is predominantly intra-cytoplasmic. However, in medullary thymocytes, it appears on the T cell surface.
Zeta’s CD3 antibody can be used in IHC to identify T cells in benign and malignant disorders. The CD3 antibody stains both membrane and cytoplasm, and is useful for classification of neoplasms. The CD3 antigen is a highly specific marker for T cells and is present in the majority of T cell neoplasms.
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