Zeta TIA-1 Antibody. Zeta’s recombinant mouse antibody recognizes TIA-1 (T cell Intracellular Antigen 1), a protein expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95)-mediated apoptosis. TIA-1 is a 17-kDa cytoplasmic granule associated protein also designated as GMP-17 (Granule Membrane Protein). Within hematopoietic cell lines, the Zeta TIA-1 antibody reacts with about 90% of CD16+, 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes. The TIA-1 antibody reacts with almost all monocytes and granulocytes. This TIA-1 antibody also reacts with CD4+ activated T-cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B-cell lines.
TIA-1 shows a granular cytoplasmic staining pattern due to its presence in cytotoxic granules. TIA-1 is involved in cytotoxic cell-mediated immune responses. TIA-1 was first identified in cytotoxic T cells; it is also expressed in normal natural killer (NK) cells and granulocytes. TIA-1 antibody is useful in characterizing neoplasms of cytotoxic T cells or NK cells.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.