CD163

    Hematopathology
    ZR426 Rabbit Monoclonal

    Zeta CD163 Antibody.  Zeta’s rabbit recombinant monoclonal antibody recognizes CD163, a protein of 140kDa. CD163 has been identified as an acute phase-regulated transmembrane protein whose function is to mediate the endocytosis of haptoglobin-hemoglobin complexes. The CD163 receptor is expressed on the surface of monocytes with low expression and on tissue macrophages, histiocytes with high expression. Staining with the antibody to CD163 has been helpful to distinguish synovial macrophages from synovial intimal fibroblasts in rheumatoid arthritis, where its specificity for macrophages was found to be superior to that of the antibody to CD68. Increased levels of CD163 were also detected in patients with microbial infections and myelomonocytic leukemias. The antibody to CD163 is of considerable value for selective identification of monocytes and macrophages at a certain stage of differentiation and is suitable for diagnosing myelomonocytic or monocytic leukaemia and neoplasms of true histiocytic origin. CD163 is positive in skin (histiocytes), gut, Kupffer cells, a few alveolar macrophages, macrophages in the placenta, and in macrophages in inflamed tissues including tumor tissue.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Liver
    Visualization:Cytoplasmic and membranous
    Isotype:IgG
    Immunogen:Recombinant human CD163 fragment (around aa 43-196)
    Ordering Information
    Classification IVD
    Catalogue Number Z2782RL
    Classification IVD (Non-EU)/ RUO (EU)
    Catalogue Number Z2782RL
    Package Inserts
    IFU-CD163 ZR426 - IVD 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    IFU-CD163 ZR426 - RUO 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS