CD14

    Hematopathology
    ZM104 Mouse Monoclonal

    Zeta CD14 Antibody.  Zeta’s recombinant mouse antibody recognizes CD14, a receptor expressed strongly on monocytes and macrophages and weakly on the surface of neutrophils and detects antigenic molecules on the surface of various microorganisms.  CD14 (also known as lipopolysaccharide receptor) is a protein of 55kDa.  CD14 is anchored to cells by linkage to glycosylphosphatidylinositol (GPI) and functions as a high-affinity receptor for complexes of LPS and LPS binding protein (LBP). Soluble CD14 binds to LPS and acts at a physiological concentration as an LPS agonist while at higher concentrations, acts as an LPS antagonizing effect in cell activation.

    CD14 is an important pattern recognition receptor that detects antigenic molecules on the surface of various microorganisms.  CD14 mutations can prevent adequate inflammatory response to infection, leading to systemic infections.  Macrophages with a protein complex of CD14, MD2 and TLR4 bind to LPS, causing macrophage activation and release of cytokines where overstimulation may cause toxic shock syndrome.

    The CD14 antibody is used to identify mature monocytes and macrophages where normal staining includes  macrophages, monocytes, Langerhans cells, dendritic cells, B cells and granulocytes.  CD14 is also expressed in chronic myelomonocytic leukemia and histiocytic scarcoma.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil or lymph node
    Visualization:Membrane and cytoplasmic
    Isotype:IgG1/ Kappa
    Immunogen:Recombinant fragment of human CD14 protein (around aa 25-148)
    Ordering Information
    Classification IVD
    Catalogue Number Z2415ML
    Classification IVD
    Catalogue Number Z2415ML
    Package Inserts
    IFU-CD14 ZM104- IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS