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    Transplantation Pathology
    ZM369 Mouse Monoclonal

    Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. C3d deposition in the renal transplant PTCs (peritubular capillaries) is indicative of AR (acute rejection)with subsequent high probability of graft loss. Anti-C3d, combined with anti-C4d, can be utilized as a tool for diagnosis of AR and warrant prompt and aggressive anti-rejection treatment. It was shown that anti-C3d labeled the epidermal basement membrane in 97% cases of bullous pemphigoid, with none of the normal controls demonstrating such findings. 27% cases of pemphigus vulgaris demonstrate intercellular C3d deposition. Therefore, C3d immunohistochemistry is a helpful adjunct in the diagnosis of bullous pemphigoid(and perhaps pemphigus vulgaris), especially in the cases in which only formalin-fixed, paraffin embedded tissue is available for analysis.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Acute rejected kidney transplant
    Visualization:Membrane or cytoplasmic
    Immunogen:Recombinant full-length human Complement C3 protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2660ML
    Classification IVD
    Catalogue Number Z2660ML
    Package Inserts
    IFU-C3d ZM369- 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.