Transplantation Pathology
    ZM78 Mouse Monoclonal

    C4d is a stable split product remnant of classical complement activation, which becomes covalently bound to endothelium and basement membrane, after induction of the classical antibody-induced pathway. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival and is an aid in treating acute rejection.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Acute rejected kidney transplant
    Visualization:Membrane or cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:Recombinant full-length human complement 4d protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2388ML
    Classification IVD
    Catalogue Number Z2388ML
    Package Inserts
    IFU-C4d ZM78
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.