ACTH

    Neuropathology/Endocrine
    ZM98 Mouse Monoclonal

    Zeta ACTH Antibody.  Zeta’s recombinant mouse monoclonal antibody recognizes ACTH (Corticotropin), a 39 amino acid active peptide produced by the anterior pituitary.  Zeta’s antibody to ACTH is specific to CLIP (aa 25-39 of ACTH) and does not react with Synacthen (aa 1-24 of ACTH). ACTH results from processing of POMC (pro-opiomelanocortin or corticotropin-lipotropin) is a 267 amino acid polypeptide hormone precursor that goes through extensive, tissue-specific posttranslational processing by convertases. POMC is cleaved into the ten hormone chains:  ACTH, NPP, alpha-MSH (Melanocyte Stimulating Hormone), beta-MSH, gamma-MSH, CLIP (corticotropin-like intermediary peptide), Lipotropin-beta, Lipotropin-gamma, beta-endorphin and Met-enkephalin. ACTH is also produced by cells of immune system (T-cells, B-cells, and macrophages) in response to stimuli associated with stress.  Zeta’s antibody to ACTH is a useful marker for the classification of pituitary tumors and the study of pituitary disease. The monoclonal antibody to ACTH reacts with ACTH-producing cells (corticotrophs).  ACTH may also react with other tumors (e.g. some small cell carcinomas of the lung) causing paraneoplastic syndromes by secreting ACTH.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Pituitary
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:Synthetic peptide corresponding to aa 25-39 of human ACTH (NGAEDESAEAFPLEF)
    Ordering Information
    Classification IVD
    Catalogue Number Z2408ML
    Classification IVD
    Catalogue Number Z2408ML
    Package Inserts
    IFU-ACTH ZM98
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS