Preferred Clone

Human neuroendocrine tumor stained with anti-Synaptophysin antibody using peroxidase-conjugate and DAB chromogen. Note the cytoplasmic staining of tumor cells.

Synaptophysin

Neuropathology/Endocrine

ZR445 Rabbit Monoclonal

This recombinant rabbit monoclonal antibody recognizes a protein of 38kDa that is identified as synaptophysin. It is an N-glycosylated integral membrane protein found in neurons and endocrine cells. Synaptophysin contains four transmembrane domains and may function as a gap junction-like channel. This antibody identifies normal neuroendocrine cells and neuroendocrine neoplasms. Diffuse, finely granular, cytoplasmic staining is observed, which probably correlates with the distribution of the antigen within neurosecretory vesicles. Synaptophysin is an independent, broad-range marker of neural and neuroendocrine differentiation.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Pancreas

Visualization:Cytoplasmic

Isotype:IgG

Immunogen:Recombinant fragment (around aa 224-313) of human Synaptophysin (SYP) protein

Ordering Information

USA International

Package Inserts

IFU-Synaptophysin ZR445 - IVD 0

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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IFU-Synaptophysin ZR445 -RUO 0

Regulatory Notice

Accept Reject

SDS