Zeta TTF-1/NKX2.1 Antibody. Zeta’s recombinant rabbit antibody recognizes TTF-1/NKX2.1, a member of the NKx2 family of homeodomain transcription factors. TTF-1/NKX2.1 codes for a protein of 40kDa. TTF-1/NKX2.1 is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive for TTF-1/NKX2.1. The TTF-1/NKX2.1 antibody is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. Zeta’s TTF-1/NKX2.1 antibody can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. Loss of TTF-1/NKX2.1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1/NKX2.1 reactivity is also seen in thyroid malignancies.
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.