Zeta Napsin-A Antibody. Zeta’s recombinant mouse antibody recognizes Napsin-A. Napsin-A is a pepsin-like aspartic proteinase connected with the maturation of surfactant protein B. There are two closely related Napsins, Napsin A and Napsin B. Napsin-A is expressed as a single-chain protein. Immunohistochemical studies revealed high expression levels of Napsin-A in the human lung and kidney but low expression in the spleen. Napsin A is expressed in type II pneumocytes and adenocarcinomas of the lung. The high specificity expression of Napsin-A in adenocarcinomas of the lung is helpful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.
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Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.