Topoisomerase IIa

    General & Epithelial Markers
    ZR94 Rabbit Monoclonal

    Zeta Topisomerase IIa Antibody.  Zeta’s recombinant rabbit antibody recognizes Topoisomerase II-α (TOP2A), a 170kDa nuclear protein that plays an important role in DNA synthesis and RNA transcription, as well as chromosomal segregation during mitosis. Topoisomerase II-α (TOP2A) is reported to be a sensitive and specific marker of late S-, G2- & M-phases in transformed and developmentally regulated normal cells and has been shown to be over-expressed in many human cancers. Decreased expression of Topoisomerase II-α is the predominant mechanism of resistance to several chemotherapeutic agents.

    Topoisomerase IIα (TOP2A) is a specific target of multiple chemotherapy drugs. Increased amplification of the TOP2A gene have been associated with treatment response in breast cancers.  Additinally, high rates of HER2 amplification were seen in patients with TOP2A amplification in breast, ovarian, gastroesophageal/oesophageal and pancreatic cancer. (Topoisomerase expression and amplification in solid tumours: Analysis of 24,262 patients – PMC (nih.gov)).

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil
    Visualization:Nucleus
    Isotype:IgG
    Immunogen:Synthetic peptide corresponding to Topo II α residues within aa1431-1531 of Topo II α
    Ordering Information
    Classification IVD
    Catalogue Number Z2404RL
    Classification IVD (Non-EU)/ RUO (EU)
    Catalogue Number Z2404RL
    Package Inserts
    IFU-Topoisomerase IIa - ZR94 - IVD 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    IFU-Topoisomerase IIa - ZR94 - RUO 0
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS