Related Products

    PCNA

    General & Epithelial Markers
    ZR378 Rabbit Monoclonal

    Zeta PCNA Antibody.  Zeta’s recombinant rabbit antibody recognizes PCNA (Proliferating Cell Nuclear Antigen), a nuclear protein with a role in DNA synthesis, DNA repair, and cell cycle progression.  PCNA expression correlates with proliferation activity.

    PCNA is a non-histone protein of 36kDa which is also known as cyclin or polymerase delta auxiliary protein. PCNA coordinates synthesis of both leading and lagging strands at the replication fork during DNA replication. Elevated expression of PCNA has been shown in the nucleus during the late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases.

    PCNA plays an important role in tumor proliferation and expression that correlates to the biological activity of tumor cells.  High PCNA protein levels may be associated with the occurrence, development, and prognosis of NSCLC.  Patients exhibiting higher PCNA protein expression had significantly shorter survival rates than the other patients. PCNA protein level and tumor pathological type, metastasis, differentiation degree, and stage were independent factors affecting the overall survival of postoperative patients (Clinical significance of high expression of proliferating cell nuclear antigen in non-small cell lung cancer – PMC (nih.gov)).

    PCNA immunohistochemical analysis can be used to define human hepatocellular carcinoma (HCC) proliferation based on its correlation with the mitotic count, histological grade, and metastasis of  HCC. HCC proliferation activity is strongly correlated with tumor invasiveness and holds potential prognostic value for human hepatocellular carcinoma (HCC) patients (Immunohistochemical detection of proliferating cell nuclear antigen in hepatocellular carcinoma – PMC (nih.gov)).

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

     

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsil, lymph node or small intestine
    Visualization:Nucleus, cytoplasm
    Isotype:IgG
    Immunogen:Recombinant full-length human PCNA protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2669RL
    Classification IVD
    Catalogue Number Z2669RL
    Package Inserts
    IFU-PCNA ZR378 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS