Zeta PCNA Antibody. Zeta’s recombinant rabbit antibody recognizes PCNA (Proliferating Cell Nuclear Antigen), a nuclear protein with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA expression correlates with proliferation activity.
PCNA is a non-histone protein of 36kDa which is also known as cyclin or polymerase delta auxiliary protein. PCNA coordinates synthesis of both leading and lagging strands at the replication fork during DNA replication. Elevated expression of PCNA has been shown in the nucleus during the late G1 phase immediately before the onset of DNA synthesis, becoming maximal during S-phase and declining during G2 and M phases.
PCNA plays an important role in tumor proliferation and expression that correlates to the biological activity of tumor cells. High PCNA protein levels may be associated with the occurrence, development, and prognosis of NSCLC. Patients exhibiting higher PCNA protein expression had significantly shorter survival rates than the other patients. PCNA protein level and tumor pathological type, metastasis, differentiation degree, and stage were independent factors affecting the overall survival of postoperative patients (Clinical significance of high expression of proliferating cell nuclear antigen in non-small cell lung cancer – PMC (nih.gov)).
PCNA immunohistochemical analysis can be used to define human hepatocellular carcinoma (HCC) proliferation based on its correlation with the mitotic count, histological grade, and metastasis of HCC. HCC proliferation activity is strongly correlated with tumor invasiveness and holds potential prognostic value for human hepatocellular carcinoma (HCC) patients (Immunohistochemical detection of proliferating cell nuclear antigen in hepatocellular carcinoma – PMC (nih.gov)).
Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists. Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.