Op18 (for oncoprotein 18, also designated stathmin, prosolin or metablastin) is a conserved, Tubulin-associated, intracellular phosphoprotein. Many different phosphorylated forms of Op18 are observed and expressed as two different isoforms. Op18 is a critical regulator of microtubulin dynamics and is downregulated by p53. It serves as a transducing protein via phophorylation for various cell signaling pathways and is involved in mitosis and differentiation. Op18 is present in many cancers, including breast carcinomas, and is highly expressed in acute leukemias of different subtypes.