Zeta S100B Antibody. Zeta’s rabbit recombinant antibody recognizes S100B, a protein that belongs to the EF-hand calcium binding proteins and is found primarily in astrocytes in the central nervous system (CNS). S100B has a variety of functions, including calcium homeostasis, cell proliferation, differentiation, migration, and survival, as well as neurite outgrowth and regeneration.
S100B is one of two family members that belong to the SB100 family of calcium binding proteins. S100A is composed of an alpha and a beta chain whereas S100B is composed of two beta chains. Zeta’s SB100B antibody is specific against an epitope located on the beta-chain (found in both S100A and S100B) but not on the alpha-chain of S-100 (S-100A and S100A0). Zeta’s S100B antibody can be used to localize S-100A and S-100B in various tissue sections.
S100B protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S100B protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S100B protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S100B protein.
To learn more about the expression and function of S100B, visit Pathology Outlines – S100 and S100B protein expression summary – The Human Protein Atlas.