Podoplanin

    Lung/Mediastinum Pathology
    ZM31 Monospecific Mouse Monoclonal

    Zeta Podoplanin Antibody.  Zeta’s recombinant mouse antibody recognizes Podoplanin (PDPN), a regulator of the lymphatic endothelium, podoplanin plays a role in maintaining the unique shape of podocytes.  The Podoplanin antibody recognizes a muco-protein of 38-43kDa located in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. Podoplanin is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, podoplanin can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.

    The Podoplanin antibody stains lymphatic channel endothelium but not in the adjacent capillary.  Additionally Podoplanin is expressed in endothelium of lymphangiomas whereas hemangiomas, glomus tumors, angiolipomas, pyogenic, vascular malformations did not show any staining.

    Zeta Corporation is a leader in recombinant monoclonal IVD antibodies for immunohistochemistry (IHC) offering 400+ tumor and tissue specific relevant products developed by a pathologist for pathologists.  Visit Precision Recombinant Antibodies – IVD Antibodies – About Zeta Corporation (zeta-corp.com) to learn more about Zeta Corporation.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Mesothelioma
    Visualization:Cytoplasmic
    Isotype:IgG1 /κ
    Immunogen:Recombinant human Podoplanin (PDPN) protein fragment (around aa 24-126)
    Ordering Information
    Classification IVD
    Catalogue Number Z2338ML
    Classification IVD
    Catalogue Number Z2338ML
    Package Inserts
    IFU-Podoplanin ZM31 - IVDL
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS